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Childhood Cancer Survivors Face Lifelong Challenges

Despite their persistence in the face of disease, survivors of childhood cancer like Lexi are at high risk for what doctors refer to as “late effects.” Chemotherapy drugs and radiation not only destroy cancer cells but also cause undetected damage to the DNA of normal cells nearby. The resulting late effects can include infertility, heart and other cardiovascular problems, neurocognitive effects, growth problems and even secondary cancers—not a metastasis but an entirely new tumor. Read more here:

UofL Physicians Conducting Vaccine Trial for Children with Relapsed Tumors at Kosair Children’s Hosp

Today, however, they and their parents are finding hope in a Phase I research study led by Kenneth G. Lucas, M.D., chief of the division of pediatric hematology/oncology and stem cell transplantation at the University of Louisville. Leading a team of his colleagues at Kosair Children’s Hospital and in the UofL Department of Pediatrics, Lucas is making progress in developing a vaccine that one day could possibly prevent recurrence of some childhood cancers. Read more here:

Children’s Cancer Is Unprofitable and Ignored

An estimated 2,000 children die of cancer each year, and the overall incidence of childhood cancer has been slowly increasing since 1975. Despite significant advances against certain pediatric cancers, including acute lymphoblastic leukemia, there are still some types of cancer for which there are few or no effective treatments. As John London found out, new drug development in the field is slow, often lagging way behind adult treatments, and few compounds are designed specifically for children. “I was on my own, as many parents are,” London says. “The medical community had no interest.” Read more here:

The Jester Has Lost His Jingle book special pricing for OPACC families

The Jester & Pharley Phund has kindly extended a special offer for OPACC families to purchase their award-winning inspirational children's book "The Jester Has Lost His Jingle" for the special discounted price of $10 USD! More information about the book from "Author David Saltzman wanted The Jester to be there for all children going through challenging times, especially children with cancer. An art and English major, David wrote and illustrated the award-winning Jester as his senior project at Yale while coping with Hodgkin's disease. He graduated with high honors in May 1989, but died not long after his graduation – on March 2, 1990, 11 days before his 23rd birthday. A

Hospital Admission Happens More Often Than Average For Young Adult Cancer Survivors Following 5 Year

Up to two decades after being declared disease-free, people first diagnosed with cancer somewhere between the ages of 20 and 44 have more hospitalizations than the general public, new research shows. Overall, young adult cancer survivors were hospitalized 1.5 times as often as people in the never-diagnosed control group, the researchers say. Read more here:

Pre-clinical Studies Suggest Anisina May Improve Chemotherapy Effectiveness in Childhood Cancer

US-Australian drug discovery company, Novogen Limited (NRT: ASX; NVGN: NASDAQ), today announced details of an in vivo proof of concept study that demonstrates their lead anti-tropomyosin drug candidate, Anisina, has the potential to improve the effectiveness of chemotherapy in children and reduce life-long side-effects. Read more here:

Cancer survivors may face barriers to adoption

Cancer survivors, who are often left infertile by the disease or treatment, may face unexpected hurdles if they later turn to adoption to start a family, a study suggests. Read more here:

Novel therapy sees viruses kill cancer cells; clinical trials announced

In a development that puts us very close to a possible therapy for cancer, researchers have devised a novel way of killing cancer cells using two viruses. Read more here:

Promising drug for childhood acute leukemia -- where to next?

A new Australian study shows that a recently-developed drug, already used safely in adult leukaemia clinical trials, holds great promise for some children with an aggressive form of cancer known as acute lymphoblastic leukaemia (ALL). Read more here:

Early Life Cancers May Leave Lifelong Emotional Scars

The risk for poor functional outcome in long-term cancer survivors is not limited to their diagnoses in early childhood, the retrospective Childhood Cancer Survivor Study (CCSS) now shows. Read more here:

Protein implicated in osteosarcoma's spread acts as air traffic controller

The investigation of a simple protein has uncovered its uniquely complicated role in the spread of the childhood cancer, osteosarcoma. It turns out the protein, called ezrin, acts like an air traffic controller, coordinating multiple functions within a cancer cell and allowing it to endure stress conditions encountered during metastasis. Read more here:

Meet a Childhood Cancer Champion: Dr. Robert Tracogna

Meet Dr. Robert Tracogna: He is a champion for our kids and is helping to raise funds and awareness by cycling with the Sears National Kids Cancer Ride across Canada this September. Dr. Tracogna is a dentist in the GTA and is a Childhood Cancer Champion as he has been riding for many years for the cause. Let's help support him by contributing stories, pictures, and, whenever possible, making a donation directly to his ride efforts! He needs your stories and pictures to inspire him through the most challenging days of the ride. If you have a story or picture of your amazing family that you would like to share, please forward it to us at and we will make sure he receives them! R

One family's experience with the CRA and disability

One of our families has experienced the following issue and we are seeking feedback from other families who may have had the same experience. Their son's disability form for tax purposes expired as of this year. They contribute to a disability savings plan for him. His doctors did not think that he will be successful in getting it approved again this time due to how the form is set up. They do not want to lose the money that was put in so far by the CRA or even have to close this account. They wanted to know what happens if he is no longer deemed disabled. They called the CRA and were told that they could get a temporary reprieve from closing the account if they get their son's doctor to wri

The Emotional Aftermath of Cancer

PTSD can occur in those who have survived or are being treated for cancer. Read more here:

Sequencing Study Sees Frequent RAS-MAPK Mutations at Neuroblastoma Relapse

In Nature Genetics, an international team led by investigators in the US, Netherlands, and France pinpointed a role for the RAS-MAPK signaling pathway in neuroblastoma relapse. Read more here:

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