"What does the world lose when a child gets cancer? Out of 2.2 billion children worldwide, more than 416,500 children are diagnosed and 142,300 are estimated to die from the disease each year. Though in hard numbers it’s a relatively small portion, each life lost is its own world of heartache and missed potential. Now researchers have calculated the impact in more defined terms. Childhood cancer’s toll amounts to a total of more than 11 million lost healthy years each year —
Survivors of childhood cancer who received ≥30 Gy of pelvic radiotherapy as treatment were at increased risk for late anorectal disease, according to the results of a Childhood Cancer Survivor study. Occurrence of this late anorectal disease had a detrimental impact on the well-being of these survivors. Read more: https://www.cancernetwork.com/news/examining-frequency-late-anorectal-disease-childhood-cancer-survivors-after-pelvic-radiation
"For the first time, Australian researchers from Children's Cancer Institute have discovered that a gene called JMJD6 plays an important role in the most aggressive form of the disease [neuroblastoma]. The research is published today in the journal, Nature Communications." Read more: https://medicalxpress.com/news/2019-07-gene-deadly-childhood-cancer-possibility.html
"A report from St. Jude Children's Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA Oncology." Read more: https://medicalxpress.com/news/2019-07-inherited-brca2-mutations-linked-childhood.html
" CAR-T is often called the “most complex drug ever created,” but it is not really a drug in the traditional sense. Unlike an inert molecule introduced to the body for some temporary effect, CAR-T is alive. If it worked as designed, this “living drug” would go on living in Emily’s bloodstream like a cancer-killing superpower, providing her with a sort of immunity against her disease. And in the process, it would give humanity a revolutionary new weapon in the war on cancer."
An evaluation of a federal benefit to help parents take time off work to care for critically ill children says fewer people have used it than expected because they didn't know about it or didn't understand how it worked. Read more: https://www.guelphtoday.com/around-ontario/canada-caregiver-benefit-for-parents-of-ill-children-largely-misunderstood-according-to-federal-review-1587777
Higher doses of anthracyclines are associated with increased risk of breast cancer in women who survived childhood cancer, regardless of whether they have mutations that predispose them to cancer, according to findings based on the St. Jude Lifetime Cohort Study. Read more: https://www.onclive.com/publications/oncology-live/2019/vol-20-no-13/higher-anthracycline-doses-linked-to-breast-malignancy-risk-in-childhood-cancer-survivors
New International Osteoporosis Foundation (IOF) Working Group publication reviews bone complications in childhood cancer survivors and provides evidence-based recommendations for the management of long-term bone health in these patients. Read more: https://www.eurekalert.org/pub_releases/2019-07/iof-lfu070219.php