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Stroke and Stroke Recurrence May Increase Mortality in Pediatric Cancer Survivors

Stroke and stroke recurrence may be associated with increased mortality and negatively impact health related quality of life (HRQOL) measures in survivors of pediatric cancer, according to a study published in Cancer. Read more: https://www.cancernetwork.com/news/stroke-and-stroke-recurrence-may-increase-mortality-pediatric-cancer-survivors

Researchers discover a new mechanism in childhood kidney cancer

"To execute their respective manuals, the cells employ so-called chromatin reader proteins that identify which gene is up for expression. Now a new study has found that a problem in this gene-regulatory process may cause normal cells to turn malignant and produce Wilms’ tumor, the most common kidney cancer in children." Read more: https://www.rockefeller.edu/news/27051-wilms-tumor-new-mechanism/

First map of circular DNA in childhood cancer

"An international team of researchers, led by Charité-Universitätsmedizin Berlin and the Memorial Sloan Kettering Cancer Center in New York now reveal that mysterious rings of DNA known as extrachromosomal circular DNA can contribute to cancer development in children." Read more: https://medicalxpress.com/news/2019-12-circular-dna-childhood-cancer.html

Immunotherapy drug improves outcomes for some children with relapsed leukemia

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia (B-ALL) that has relapsed. Read more: https://www.eurekalert.org/pub_releases/2019-12/nci-idi120919.php

Why The Obsession With A Universal Cure For Cancer May Be Harming Research And Patients

"So why can’t we strive for one universal cure for cancer? Because cancer is not one disease, it is broadly 200 different diseases, each of these with a host of different intricate subtypes." Read more: https://www.forbes.com/sites/victoriaforster/2019/12/08/why-the-obsession-with-a-universal-cure-for-cancer-may-be-harming-research-and-patients/#e32d60f163e4

Root of childhood kidney cancer discovered

"A fundamental change in our understanding of the childhood kidney cancer Wilms' tumour is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators." Read more: https://medicalxpress.com/news/2019-12-root-childhood-kidney-cancer.html

Neuroblastoma: Improved treatment prospects in future

"A research team led by molecular pathologist Lukas Kenner from MedUni Vienna's Department of Pathology has now discovered, through genome sequencing, that the protein ALK and the cancer gene PIM1 are involved in the development of this tumor." Read more: https://medicalxpress.com/news/2019-12-neuroblastoma-treatment-prospects-future.html

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