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Tumour cell of origin in childhood malignant glioma impacts susceptibility to cancer therapy

Children that are diagnosed with the severe the brain tumour malignant glioma often have a very poor prognosis. Knowledge about how pediatric malignant glioma arises and develops is still limited. New findings from Uppsala University show that in mice glioma development and glioma cell properties are affected by both age and the cell type from which the tumour has arisen. The tumour cell of origin was also important for the susceptibility of the tumour cells towards cancer drugs. Read more: http://www.news-medical.net/news/20161117/Tumour-cell-of-origin-in-childhood-malignant-glioma-impacts-susceptibilityc2a0to-cancer-therapy.aspx

Most Adult Survivors of Childhood Cancer Discontinue Needed Long-Term Follow-Up Care

The first comprehensive study analyzing follow-up care among childhood cancer survivors concludes that fewer than half of the adult survivors of childhood cancers — who remain at greater risk for chronic illnesses — receive adequate long-term follow-up care. Read more: http://journals.lww.com/oncology-times/blog/onlinefirst/Pages/post.aspx?PostID=1516

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

Treatment with a higher total cumulative dose of cisplatin, young age, and concomitant furosemide administration are associated with an increased risk of ototoxicity in childhood cancer survivors treated with platinum-based therapy, according to a study published in the European Journal of Cancer. Read more: http://www.oncologynurseadvisor.com/side-effect-management/study-identifies-factors-associated-with-platinum-induced-ototoxicity/article/573305/

Childhood Cancer Survivors: Genetic Clues Help Prevent Late Effects

[...] although the main focus of research continues to be the 20% of children who are not surviving, researchers are also recognizing the heavy burden of long-term morbidity and premature mortality directly related to treatment. Read more here: http://www.medscape.com/viewarticle/871724

Retinoblastoma studies at SickKids

Dr. Helen Dimaras (Scientist, Hospital for Sick Children, Toronto) is inviting retinoblastoma survivors and their families to participate in two research studies. What’s the Purpose of These Studies? The purpose of the first study is to gather information about the experiences, knowledge, research interests, and communication preferences of retinoblastoma survivors and their families. If you are eligible, you will be invited to complete a brief survey and then participate in a focus group. A focus group is a discussion, lasting up to 2.5 hours, involving up to ten retinoblastoma survivors or the immediate family of someone diagnosed with retinoblastoma. The purpose of the second study is to

Tools to Help Assess Your Child’s Cancer Pain

When your child is in pain, everything else falls by the wayside. When you are able to assess and manage their pain, your child, your family and those around you can concentrate on making the best out of every day. Read more here: https://cancerkn.com/tools-help-assess-childs-cancer-pain/?platform=hootsuite

Cardiac mortality risk elevated in patients diagnosed with cancer at young age

Patients diagnosed with cancer at age 15 to 19 years who survived at least 5 years had a higher risk for cardiac death compared with patients with a later diagnosis and the general population, according to new data. Read more here: http://www.healio.com/cardiology/chd-prevention/news/online/%7B66d082ee-3410-4646-b5a7-c9ab7746ec1a%7D/cardiac-mortality-risk-elevated-in-patients-diagnosed-with-cancer-at-young-age

Childhood cancer survivors living longer, but health suffers

Thanks to improvements in cancer treatment, childhood cancer survivors are now living longer than ever. But new research suggests that they continue to suffer from health issues down the road. Read more: http://www.cbsnews.com/news/childhood-cancer-survivors-living-longer-but-not-in-better-health/

Michael Bublé says 3-year-old son Noah has cancer

**OPACC was quoted in this story** In a posting on his Facebook page, the Burnaby, B.C., native says he and wife Luisana Lopilato are ‘devastated’ by three-year-old Noah’s diagnosis. Read more here: https://www.thestar.com/entertainment/music/2016/11/04/michael-buble-says-3-year-old-son-noah-has-cancer.html

Review Supports Dexrazoxane Use for Cardioprotection

The practice of giving dexrazoxane to protect the hearts of pediatric patients receiving anthracycline chemotherapy is supported by a review published in the British Journal of Clinical Pharmacology. Read more here: http://www.clinicaloncology.com/Current-Practice/Article/11-16/Review-Supports-Dexrazoxane-Use-for-Cardioprotection/38474

New OPACC Lunch & Learn

OPACC's free informational "Lunch & Learn" series continues with its latest installment, "Making Decisions in Extreme Circumstances" How do you decide when facing a life threatening situation? You have made millions of decisions in your lifetime. Some were easy, some were difficult, but nothing can be compared to a situation where your child's life is at stake. Decision-making in a life or death situation may be extremely challenging when it is all about the most important thing in your life and your decision-making capabilities become altered by this trauma. This one-hour workshop aims at making you realize that, although you are living an unusual and extremely difficult situation, fortunat

Antibody breaks leukemia's hold, providing new therapeutic approach

Acute myeloid leukemia (AML) is an aggressive cancer known for drug resistance and relapse. In an effort to uncover new treatment strategies, researchers have discovered that a cell surface molecule known as CD98 promotes AML. Read more here: https://www.sciencedaily.com/releases/2016/10/161028115152.htm

Cancer MoonShot 2020 Milestone: Announcing Launch of the Nation’s Largest Pediatric Brain Tumor Atla

The first major project of the Pediatric Cancer MoonShot 2020 Consortium with a $20MM Award from the Chan Soon-Shiong Institute of Molecular Medicine to enable the most comprehensive molecular analysis of brain tumors of all types in children Goal is to release genomic, transcriptomic and proteomic data from 1,600 patients in next six months, representing the nation's largest brain tumor atlas to date. Read more here: http://www.businesswire.com/news/home/20161028005639/en/Cancer-MoonShot-2020-Milestone-Announcing-Launch-Nation%E2%80%99s

Scientists Tackle Lethal Childhood Brain Cancer

Today, however, the outlook for DIPG and other childhood brain cancers looks more promising, thanks to a surge of new research made possible by advances in gene-sequencing methods and tumor tissue donations from families who have lost children, such as Andrew, to these diseases. Read more here: https://www.scientificamerican.com/article/scientists-tackle-lethal-childhood-brain-cancer/

Promise of better targeted treatments now possible in children's brain cancer

Writing this week in the journal Cell Reports, researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue. Read more here: https://www.eurekalert.org/pub_releases/2016-10/uouh-pob102616.php

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