Researchers have uncovered the mechanisms behind three unique subtypes of mismatch repair deficient high-grade gliomas. The findings provide a clearer understanding of how these tumors develop, explain why patients respond differently to immunotherapy, and are already helping guide more precise therapies. Read more: https://medicalxpress.com/news/2026-02-discovery-unique-brain-tumor-subtypes.html

A major study by UCL and Fondazione IRCCS Istituto Nazionale dei Tumori in Milan (INT) researchers has for the first time shown in detail how far children's cancer has spread at diagnosis in a way that can be compared between countries. Read more: https://medicalxpress.com/news/2026-02-registry-analysis-links-year-childhood.html

How to reduce suffering in children with advanced cancer remains an ongoing but urgent question. A Mass General Brigham-led study examined whether systematically surveying children with advanced cancer and their parents about their symptoms and quality of life, providing feedback to children, families, and clinicians-and acting on that information by implementing personalized palliative care-could improve patients' experiences. Read more: https://www.news-medical.net/news/202

In a study published in Nature , University of Michigan researchers have found that a specific molecule called itaconate drives the development of ependymomas. Their findings can help future drug development for children with this type of malignant brain tumor. Read more: https://www.michiganmedicine.org/health-lab/itaconate-identified-new-target-pediatric-brain-tumors-called-ependymomas

A world-first trial of a personalised vaccine for children with deadly brain cancers will be rolled out in eight hospitals throughout Australia later this year.  Read more: https://www.abc.net.au/news/2026-02-03/brain-cancer-vaccine-trial-for-children/106294532

A new national study highlights both common ground and key diverging factors between parents and clinicians on what psychosocial needs matter most for children with cancer. Read more: https://journals.lww.com/oncology-times/fulltext/2026/02000/parents___clinicians_diverge_on_psychosocial.2.aspx

Knowledge Mobilization Group seeks to understand the knowledge mobilization needs of the childhood cancer community from the perspectives of both children and adults. Read more: https://www.mcgill.ca/nursing/article/pan-canadian-research-team-dedicated-improving-lives-children-cancer-and-their-families

The FDA approved a larger nelarabine vial to improve dosing flexibility and simplify treatment for adult and pediatric patients with T-ALL and T-LBL.   Read more: https://www.curetoday.com/view/fda-approves-larger-nelarabine-vial-for-some-leukemias-and-lymphomas