Nearly half of childhood tumors treated with common types of chemotherapy showed detectable DNA changes linked to treatment within 18 months, according to a new international study led by The Hospital for Sick Children (SickKids). Researchers say these changes could eventually help clinicians spot treatment resistance earlier, before cancer returns or spreads, opening the door to a more precise use of chemotherapy. Read more: https://www.news-medical.net/news/20260723/Chemot

Scientists from St. Jude Children’s Research Hospital and collaborators have identified the RNA-binding protein RBM5 as a potential vulnerability in a set of difficult-to-treat childhood leukemias. Read more: https://www.stjude.org/media-resources/news-releases/2026-medicine-science-news/targeting-rbm5-may-help-disrupt-undruggable-myc-in-childhood-leukemia.html

Among Ewing sarcoma (EWS) survivors, rates of late mortality, subsequent malignant neoplasms (SMNs), and certain chronic health conditions (CHCs) do not significantly differ between 2 chemotherapy regimens, according to research published in Cancer. Read more: https://www.cancertherapyadvisor.com/news/ewing-sarcoma-survivors-elevated-long-term-health-mortality-risks/

Now, a new Phase 1 trial led by researchers at Children’s National Hospital showed that a new autologous multi-antigen T cell therapy can be delivered intravenously and reach the brain through the bloodstream to fight off brain tumors in children. Read more: https://www.drugdiscoverynews.com/new-autologous-t-cell-therapy-offers-hope-for-children-with-brain-tumors-17325

A pediatric cancer diagnosis can create financial toxicity that extends far beyond treatment, affecting families through caregiving demands, lost income, and, for many survivors, decades of long-term health and financial consequences. Read more: https://www.ajmc.com/view/pediatric-cancer-creates-long-term-financial-challenges-for-patients-families-cherie-daly-md

Researchers from Fox Chase Cancer Center have identified a widely used thyroid hormone that may significantly improve treatment outcomes for medulloblastoma, the most common malignant brain tumor in children. Read more: https://medicalxpress.com/news/2026-07-common-thyroid-hormone-brain-tumor.html

Children and young adults with metastatic non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) continue to have “poor” survival outcomes despite the use of adaptive ifosfamide plus doxorubicin-based multimodal therapy, according to research published in the Journal of the National Cancer Institute. Read more: https://www.cancertherapyadvisor.com/news/outcomes-poor-children-non-rhabdomyosarcoma-soft-tissue-sarcoma/

A study has found that children continuously exposed to air pollutants generated during vehicle traffic, such as automobile exhaust, may face a higher risk of developing childhood cancers. Read more: https://www.chosun.com/english/national-en/2026/07/06/YPFTIRO4YNATBCAWYFJGJPFSC4/

Researchers at Karolinska Institutet have demonstrated that it is possible to create early germ cells from preserved testicular tissue of young boys facing cancer therapy. The study, published in the journal Human Reproduction Open, may eventually contribute to new ways of protecting and restoring fertility after childhood cancer. Read more: https://medicalxpress.com/news/2026-07-testicular-tissue-early-germ-cells.html

A large European consortium will investigate environmental factors that may cause cancer in children, teenagers, and young adults. An increase in cancer diagnoses among adolescents and young adults suggests that environmental exposures may play a greater role than previously thought. Read more: https://www.prinsesmaximacentrum.nl/en/news/major-eu-study-to-investigate-the-role-of-environmental-factors-in-childhood-cancer