A research team from the Children's Hospital of Chongqing Medical University, China, reported in Pediatric Discovery  that thiostrepton can significantly suppress rhabdomyosarcoma progression by targeting the PI3K-AKT signaling pathway. Read more: https://www.news-medical.net/news/20251027/Study-finds-evidence-for-repurposing-thiostrepton-as-an-anti-rhabdomyosarcoma-drug.aspx

The FDA granted rare pediatric disease designation to iopofosine-131 for treating relapsed or refractory pediatric high-grade glioma.   Read more: https://www.curetoday.com/view/fda-grants-rare-pediatric-designation-for-iopofosine-131-in-glioma-subset

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form—but instead of fueling progress, they supercharge disease. That’s what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer. Read more: https://www.futurity.org/rna-droplet-hubs-cancer-growth-3302132/

What if a single test could simultaneously contribute to the diagnosis, characterization, and treatment guidance of childhood cancer—while helping avoid toxic or potentially unnecessary treatments? Read more: https://medicalxpress.com/news/2025-10-rapid-comprehensive-genetic-diagnosis-pediatric.html

When the researchers increased the amount of HIF2α in neuroblastoma cells with many copies of the MYCN gene, they observed a significant reduction in MYCN protein levels. Read more: https://medicalxpress.com/news/2025-10-higher-hif2-aggressive-childhood-cancer.html

A new study led by researchers at the University of Minnesota Medical School has identified genetic factors that may help explain why African American children are less likely to develop acute lymphoblastic leukemia (ALL) but tend to face worse outcomes when they do. Read more: https://twin-cities.umn.edu/news-events/university-minnesota-study-uncovers-new-genetic-factors-childhood-leukemia

First late effects study since new treatments were introduced found high prevalence of hearing loss, growth failure, underweight and lung disease. Read more: https://www.eurekalert.org/news-releases/1102637

A research team from the University of Zurich and the University Children's Hospital Zurich has developed a new approach for treating children with malignant tumors of the nervous system. By combining an approved drug with a specialized diet, they were able to slow down tumor growth and stimulate cancer cells to mature into normal nerve cells. Read more: https://www.news-medical.net/news/20251021/Researchers-develop-a-new-approach-for-treating-children-with-neuroblastoma.aspx

Children whose mothers lived near farms and fields treated with certain pesticides during pregnancy have a higher risk of a deadly cancer that is most commonly found in infants before their first birthday, according to a new study.  Read more: https://www.thenewlede.org/2025/10/pesticides-child-cancer-california/

Using fruit flies, University of Wisconsin–Madison researchers have developed a new model for investigating the genetic drivers of a rare but aggressive brain tumor in children. The work has already identified potential treatment targets for the deadly cancer that has previously had few therapeutic options. Read more: https://medicalxpress.com/news/2025-10-uncover-treatment-devastating-childhood-brain.html