A non-profit organization merges engineering and biology to accelerate drug development for childhood cancers. Read more: https://www.nature.com/articles/d41586-022-01513-5

Young adults who have survived leukemia have higher mortality rates than people in the general population, even for decades after their treatment, according to a new study. Read more: https://www.forbes.com/sites/victoriaforster/2022/05/27/young-adult-blood-cancer-survivors-face-increased-risk-of-death-for-decades-after-treatment/?sh=38406eb1339e

The Food and Drug Administration (FDA) approved Vidaza (azacytidine) for the treatment of pediatric patients with newly diagnosed juvenile myelomonocytic leukemia, a rare blood cancer where certain types of white blood cells do not mature normally. Read more: https://www.curetoday.com/view/fda-approves-vidaza-for-rare-pediatric-blood-cancer

New research from Baylor College of Medicine and Texas Children’s Cancer Center characterizes a new molecular type of high-risk pediatric liver cancer. The study, published in the Journal of Hepatology, showed that these tumors have better outcomes when patients were treated by transplantation, rather than by chemotherapy and surgery alone. Read more: https://www.bcm.edu/news/new-molecular-subset-of-pediatric-liver-cancer-identified

The results may have important implications for treatment of boys with cancer, for whom chemotherapy may be preceded by harvesting and freezing of testicular tissue for eventual reimplantation. Read more: https://www.eurekalert.org/news-releases/951471

Scientists have pinpointed a possible new target for treating patients with the blood cancer juvenile myelomonocytic leukaemia (JMML), according to a new study. Read more: https://www.sciencedaily.com/releases/2022/05/220510102932.htm

Increased risks of several solid tumors found to be associated with radioactive iodine treatment for patients with childhood and young-adulthood differentiated thyroid cancer. Read more: https://www.targetedonc.com/view/rai-treatment-in-dtc-survivors-associated-with-increased-risk-of-other-cancers

Death due to a second primary cancer occurred nearly twice as often among adolescent and young adult cancer survivors compared with the general population, according to study results published in Journal of the National Cancer Institute. Read more: https://www.healio.com/news/hematology-oncology/20220504/aya-cancer-survivors-at-higher-risk-for-death-due-to-second-primary-cancers

This rare and aggressive form of childhood liver cancer shares enough similarities with its adult counterpart to make it a good disease for which to study immunotherapy treatments. Read more: https://answers.childrenshospital.org/liver-immunotherapy/

In studies using mice grafted with human Ewing sarcoma tissue, researchers from Georgetown University Medical Center and colleagues have identified a biological pathway that is activated when tissue is starved of oxygen due to rapid growth of a tumor, thereby allowing cancer cells to make genetic changes so they can metastasize to the bone and thrive even when exposed to chemotherapy. Read more: https://medicalxpress.com/news/2022-04-biological-pathways-genomic-bone-meta