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Uncovering molecular targets for childhood cancer therapeutics

In the past two decades, despite extensive efforts to identify the genes associated with 11q aberrations in NB, definitive answers are still unclear. This distinct gap in the field has spurred a team of Tokyo Medical and Dental University (TMDU)-centered researchers to investigate the role of the gene ATM and DNA damage response (DDR)-associated molecules located in 11q. A report of the results was recently published. Read more: https://medicalxpress.com/news/2017-12-uncovering-molecular-childhood-cancer-therapeutics.html

Major Study Indicates That Therapy Dogs Provide Significant Benefits to Families of Children Undergo

Following seven years of pioneering research, American Humane, the country's first national humane organization, revealed the results of its long-awaited "Canines and Childhood Cancer Study," the first and largest randomized, controlled clinical trial to rigorously measure the effects of animal-assisted therapy (AAT) in the field of pediatric oncology. The results, published today in the Journal of Pediatric Oncology Nursing, furnish evidence that regular visits from a therapy dog can provide significant psychosocial benefits to families of children undergoing treatment for cancer. Read more: https://www.prnewswire.com/news-releases/english-releases/major-study-indicates-that-therapy-dogs-pr

Childhood, testicular cancers increase risk for hypogonadism

Men who are survivors of childhood cancer or testicular cancer are at markedly increased risk for developing hypogonadism vs. men in the overall population, with the risk rising for men who underwent testicular or cranial irradiation or combination chemotherapy plus radiotherapy, according to a study. Read more: https://www.healio.com/endocrinology/reproduction-androgen-disorders/news/in-the-journals/%7Bf335adb5-dd18-49b0-9074-e3d9f38cfedd%7D/childhood-testicular-cancers-increase-risk-for-hypogonadism

When a Sibling Dies, or Has a Serious Illness

About 5 to 8 percent of children in the United States will experience the death of a sibling, but the loss is rarely discussed, and siblings of terminally ill children are often overlooked. Read more: https://www.nytimes.com/2017/12/12/well/family/siblings-death-brother-sister-fatal-illness-disease.html

Childhood Leukemia Outcomes May Be Informed by DNA Methylation Patterns

Two studies by independent research teams have identified epigenetic subgroups in children with a rare pediatric leukemia called juvenile myelomonocytic leukemia (JMML) that may offer prognostic clues. Read more: https://www.genomeweb.com/cancer/childhood-leukemia-outcomes-may-be-informed-dna-methylation-patterns

Cancer Survivors Often Face Another Hurdle: Faster Aging

Treatments that help people beat cancer also can cause them to age prematurely and die sooner, Mayo Clinic researchers report. Read more: https://health.usnews.com/health-care/articles/2017-12-19/cancer-survivors-often-face-another-hurdle-faster-aging

Molecular super enhancers: A new key for targeted therapy of brain cancer in children

Ependymoma refers to a heterogeneous group of cancers that can occur at any age and is one of the most common types of brain cancer in children. The genetic causes for its development are largely unknown and there are no targeted treatments to date. Scientists from the "Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ), in collaboration with colleagues from the U.S.A. and Canada, have now developed a molecular approach that opens new treatment prospects. Read more: https://www.eurekalert.org/pub_releases/2017-12/gcrc-mse121817.php

Study finds differences between adult and childhood leukemia, calls for developing age-specific canc

A study conducted by Fred Hutchinson Cancer Research Center, with contributions from researchers across North America, has found stark differences between children and adults with acute myeloid leukemia (AML), a common kind of cancer that has increased slightly among children. Read more: https://www.geekwire.com/2017/study-finds-differences-adult-childhood-leukemia-calls-developing-age-specific-cancer-treatments/

Immunotherapy drug nearly eliminates severe acute graft-versus-host disease

Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants. Read more: https://www.eurekalert.org/pub_releases/2017-12/sc-idn120717.php

New Immunotherapy for Deadly Childhood Brain Cancer Targets Novel 'Neoantigen'

Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against a mutant form of a protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers. Read more: https://www.ucsf.edu/news/2017/12/409196/new-immunotherapy-deadly-childhood-brain-cancer-targets-novel-neoantigen

Games on Demand game jam takes requests from ill children

Susan Kuczynski is an OPACC parent liaison. She says that it’s vital to have events where the kids can simply be themselves. Activities like playing video games or a sport like basketball can be empowering and give them a much-needed creative outlet. Read more: https://venturebeat.com/2017/11/30/games-on-demand-game-jam-takes-request-from-ill-children/

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