CAR T cell therapies targeting B7-H3 (CD276), a marker expressed on DIPG tumors, have been tested in early phase clinical trials and demonstrated feasibility and tolerability. [...] However, many CAR T cells may struggle to travel into the tumor and exert their cancer-killing effects. Read more: https://www.fredhutch.org/en/news/spotlight/2026/01/ccsg-song-natcomm.html

Long term survivors of childhood cancer may carry a measurable brain age gap decades after treatment, according to a cross-sectional analysis from the St. Jude Lifetime Cohort Study. Read more: https://www.emjreviews.com/neurology/news/accelerated-brain-aging-tied-to-neurocognition/

Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. Read more: https://medicalxpress.com/news/2025-12-machine-statin-phenothiazine-combo-neuroblastoma.html

In a groundbreaking study published in Pediatric Research, researchers have unveiled compelling evidence revealing the profound psychological burden borne not only by childhood cancer survivors but also by their parents. Read more: https://bioengineer.org/ptsd-depression-anxiety-in-childhood-cancer-survivors-parents/

Survivors of childhood cancer often do not know enough about their diagnosis and treatment to help prevent related health problems as adults, a study suggests. Read more: https://utdailybeacon.com/131065/news/adults-ignorant-of-medical-history/

A large cohort study shows that meningiomas develop years later in a significant minority of survivors, with higher risks linked to treatment at earlier ages, radiation exposure, and certain chemotherapies. Read more: https://www.emjreviews.com/neurology/news/study-tracks-risk-of-meningiomas-in-childhood-cancer-survivors/