Dual therapy shows promise for childhood brain cancer
In a new study, Children’s Cancer Institute and UNSW Sydney researchers lab-tested a combined therapy approach on a group of difficult-to-treat brain tumours: diffuse midline gliomas (DMG). This group includes diffuse intrinsic pontine glioma (DIPG), a rare but fatal childhood brain cancer. Read more: https://www.unsw.edu.au/newsroom/news/2026/01/dual-therapy-shows-promise-for-childhood-brain-cancer
Jan 20
Guiding the attack: CXCR3 leads CAR T cells to pediatric brain tumors
CAR T cell therapies targeting B7-H3 (CD276), a marker expressed on DIPG tumors, have been tested in early phase clinical trials and demonstrated feasibility and tolerability. [...] However, many CAR T cells may struggle to travel into the tumor and exert their cancer-killing effects. Read more: https://www.fredhutch.org/en/news/spotlight/2026/01/ccsg-song-natcomm.html
Jan 13
Ultrasound-Driven Microbubbles Cross Blood-Brain Barrier to Treat Childhood Cancer
Ultrasound-created microbubbles can deliver anti-cancer drugs to tumors in difficult-to-reach areas such as the brain stem and spinal cord, a pilot study in children has revealed. Read more: https://www.insideprecisionmedicine.com/topics/oncology/ultrasound-driven-microbubbles-cross-blood-brain-barrier-to-treat-childhood-cancer/
Dec 1, 2025
FDA Grants Breakthrough Therapy Designation for BrainChild Bio’s B7-H3 CAR T-Cell Therapy for Incurable Pediatric Brain Tumors
BrainChild Bio, Inc., a clinical-stage biotechnology company developing CAR T-cell therapies to treat tumors in the central nervous...
Jun 28, 2025
Trial Shows Targeted Treatment for Childhood Brain Tumor is Safe
A Phase I clinical trial demonstrated that a targeted approach to treating a deadly brain tumor in children called diffuse intrinsic...
Apr 7, 2025
Experimental treatment borrowed from blood cancer shows promise for pediatric brain tumors
In an early-stage clinical trial, the therapy nearly doubled the expected survival time of young patients. Still, experts caution that...
Mar 24, 2025
Study finds pediatric brain tumors rely on different metabolic 'route' to fuel treatment resistance
Rogel researchers, led by Daniel Wahl, M.D., Ph.D., wanted to understand how this mutation affects DIPG tumor metabolism and influences...
Jun 18, 2024
First child cured of rare brain tumor 'offers real hope'
The Belgian boy is the first child in the world to have been cured of brainstem glioma, a particularly brutal cancer, according to the...
Feb 22, 2024
Blocking Immune Molecule Prolongs Survival in Models of the Most Aggressive Childhood Cancer
Researchers demonstrate that TIM-3 inhibition promotes immune memory in diffuse intrinsic stem glioma (DIPG). Read more:...
Oct 13, 2023
New drug candidate nearly doubles survival for patients with aggressive childhood brain tumors
For the first time, researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain...
Aug 21, 2023