A new study led by researchers at the University of Minnesota Medical School has identified genetic factors that may help explain why African American children are less likely to develop acute lymphoblastic leukemia (ALL) but tend to face worse outcomes when they do. Read more: https://twin-cities.umn.edu/news-events/university-minnesota-study-uncovers-new-genetic-factors-childhood-leukemia

First late effects study since new treatments were introduced found high prevalence of hearing loss, growth failure, underweight and lung disease. Read more: https://www.eurekalert.org/news-releases/1102637

A research team from the University of Zurich and the University Children's Hospital Zurich has developed a new approach for treating children with malignant tumors of the nervous system. By combining an approved drug with a specialized diet, they were able to slow down tumor growth and stimulate cancer cells to mature into normal nerve cells. Read more: https://www.news-medical.net/news/20251021/Researchers-develop-a-new-approach-for-treating-children-with-neuroblastoma.aspx

Children whose mothers lived near farms and fields treated with certain pesticides during pregnancy have a higher risk of a deadly cancer that is most commonly found in infants before their first birthday, according to a new study. Read more: https://www.thenewlede.org/2025/10/pesticides-child-cancer-california/

Using fruit flies, University of Wisconsin–Madison researchers have developed a new model for investigating the genetic drivers of a rare but aggressive brain tumor in children. The work has already identified potential treatment targets for the deadly cancer that has previously had few therapeutic options. Read more: https://medicalxpress.com/news/2025-10-uncover-treatment-devastating-childhood-brain.html

A groundbreaking study led by researchers at Children’s Hospital Los Angeles offers critical insights into Ewing Sarcoma, a rare and aggressive bone and soft tissue cancer that primarily affects children and adolescents. Read more: https://www.morningstar.com/news/business-wire/20251013103275/childrens-hospital-los-angeles-researchers-discover-possible-cell-of-origin-for-ewing-sarcoma

Researchers at Cleveland Clinic Children’s have helped identify a previously unknown gene that increases the risk of developing osteosarcoma, the most common type of malignant bone tumor in children and young adults. Read more: https://newsroom.clevelandclinic.org/2025/10/09/new-research-reveals-genetic-link-to-most-common-pediatric-bone-cancer

The FDA has granted orphan drug designation (ODD) to AMXT 1501 in combination with difluoromethylornithine (Iwilfin; DFMO) for the treatment of patients with neuroblastoma. Read more: https://www.targetedonc.com/view/amxt-1501-and-dfmo-combination-achieve-fda-orphan-drug-designation

It is the leading cause of disease-related death in children, and while the five-year survival rate now stands at 85%, the diagnosis can send a wave of devastation, fear, anxiety and helplessness through not only the child, but also surrounding family, friends and community members. Read more: https://www.yourvalley.net/paradise-valley-independent/stories/we-cant-neglect-the-mental-toll-of-a-childhood-cancer-diagnosis,620036

Siblings’ emotional and developmental needs are affected across the course of a child’s cancer — not only at end of life. The research highlights the importance of screening for sibling distress and offering supports (peer support, counseling, family-centered communication, and validated sibling assessment tools). Read more: https://www.acco.org/for-siblings/