Researchers at Children's Hospital of Philadelphia (CHOP) and Children's National Hospital in Washington D.C. are uncovering how rare inherited genetic variants contribute to the development of brain and spinal cord tumors in children. Read more: https://www.prnewswire.com/news-releases/researchers-highlight-genetic-factors-in-pediatric-brain-and-spinal-cord-tumors-302623472.html

Lava-dwelling lizards, cells playing dead and a century-old evolutionary theory – understanding the way childhood cancers resist treatment is proving to be quite a ride. Read more: https://news.cancerresearchuk.org/2025/11/18/exploring-the-hidden-survival-tactics-of-childhood-cancers/

Cancer treatment balances on a razor’s edge. On one side, physicians must use enough of a drug to kill tumor cells effectively. On the other side, a high drug concentration can be harmful to a patient’s normal cells. In children, the difference between the two, called the therapeutic index, is small.  Read more: https://www.stjude.org/research/progress/2025/finding-balance-between-efficacy-and-toxicity-in-pediatric-cancer-treatment.html

What if a single test could simultaneously contribute to the diagnosis, characterization, and treatment guidance of childhood cancer—while helping avoid toxic or potentially unnecessary treatments? Read more: https://medicalxpress.com/news/2025-10-rapid-comprehensive-genetic-diagnosis-pediatric.html

A new study led by researchers at the University of Minnesota Medical School has identified genetic factors that may help explain why African American children are less likely to develop acute lymphoblastic leukemia (ALL) but tend to face worse outcomes when they do. Read more: https://twin-cities.umn.edu/news-events/university-minnesota-study-uncovers-new-genetic-factors-childhood-leukemia

Dr. Kim E. Nichols leans on findings from the Pediatric Cancer Genome Project to discover the role genes and ancestry play in the development of cancer. Read more: https://www.stjude.org/inspire/news/dr-kim-nichols-cancer-predisposition-clinic.html

A five-year project using genetics, genomics and data to improve cancer diagnostics and treatment for children could "change what we...

Researchers at the Wellcome Sanger Institute, Cambridge University Hospitals NHS Foundation Trust, Great Ormond Street Hospital, the...

New research from Dana-Farber Cancer Institute has found that rare germline genetic abnormalities could increase the risk of childhood...

Hereditary changes in genes are often the cause of rare diseases. [...] In this context, researchers at the Hannover Medical School (MHH)...