Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a potentially new treatment strategy aimed at immunologically “cold” tumors by restoring their ability to present antigens to the immune system. Read more: https://www.insideprecisionmedicine.com/topics/oncology/new-approach-to-treating-cold-neuroblastoma-developed/

Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. Read more: https://medicalxpress.com/news/2025-12-machine-statin-phenothiazine-combo-neuroblastoma.html

Children with a rare form of cancer called neuroblastoma which hasn’t responded to initial treatment or that has relapsed may benefit from adding antibody treatment to usual chemotherapy, according to new results from a clinical trial. Read more: https://www.birmingham.ac.uk/news/2025/adding-antibody-treatment-to-chemo-boosts-outcomes-for-children-with-rare-cancer

A discovery from Australian researchers could lead to better treatment for children with neuroblastoma, a cancer that currently claims 9 out of 10 young patients who experience recurrence. The team at the Garvan Institute of Medical Research in Sydney, Australia, found a drug combination that can bypass the cellular defenses these tumors develop that lead to relapse. Read more: https://medicalxpress.com/news/2025-11-drug-combination-sidesteps-resistance-aggressive.html

Despite major therapeutic advances, survival rates remain lower for children from socioeconomically disadvantaged families, a pattern long observed and poorly understood at the biological level. Read more: https://medicalxpress.com/news/2025-11-food-insecurity-linked-tumor-growth.html

When the researchers increased the amount of HIF2α in neuroblastoma cells with many copies of the MYCN gene, they observed a significant reduction in MYCN protein levels. Read more: https://medicalxpress.com/news/2025-10-higher-hif2-aggressive-childhood-cancer.html

First late effects study since new treatments were introduced found high prevalence of hearing loss, growth failure, underweight and lung disease. Read more: https://www.eurekalert.org/news-releases/1102637

A research team from the University of Zurich and the University Children's Hospital Zurich has developed a new approach for treating children with malignant tumors of the nervous system. By combining an approved drug with a specialized diet, they were able to slow down tumor growth and stimulate cancer cells to mature into normal nerve cells. Read more: https://www.news-medical.net/news/20251021/Researchers-develop-a-new-approach-for-treating-children-with-neuroblastoma.aspx

Children whose mothers lived near farms and fields treated with certain pesticides during pregnancy have a higher risk of a deadly cancer that is most commonly found in infants before their first birthday, according to a new study.  Read more: https://www.thenewlede.org/2025/10/pesticides-child-cancer-california/

The FDA has granted orphan drug designation (ODD) to AMXT 1501 in combination with difluoromethylornithine (Iwilfin; DFMO) for the treatment of patients with neuroblastoma. Read more: https://www.targetedonc.com/view/amxt-1501-and-dfmo-combination-achieve-fda-orphan-drug-designation