Lenalidomide Demonstrates Promising Activity in Pediatric Gliomas/Astrocytomas
The immunomodulatory agent lenalidomide (Revlimid) appeared clinically active and tolerable in pilocytic astrocytomas and optic pathway...
Jul 6, 2023
Developing novel treatments for childhood solid cancers
With a particular focus on glioma, Dr Peter J Houghton from Greehey Children’s Cancer Research Institute outlines the barriers that have...
Jul 4, 2023
New Drug Shows ‘Encouraging’ Outcomes for Pediatric Brain Tumor Treatment
Treatment with tovorafenib led to a 64% overall response rate in patients with recurrent or progressive pediatric low-grade glioma, study...
Jan 12, 2023
Dabrafenib + Trametinib Improve Overall Response Rates in Pediatric Patients with Low-Grade Gliomas
The combination of two targeted therapies, the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib, significantly increased the...
Jun 9, 2022
Study finds jumping 'junk' DNA is a novel cause of childhood brain cancer
Scientists have found a novel cause of aggressive pediatric brain cancer. The St. Jude Children's Research Hospital study is the first to...
Apr 26, 2022
Alcohol abuse drug may hold key to treating aggressive childhood brain tumours
Researchers at University College London have discovered that disulfiram, an anti-alcoholism drug, may help to kill glioma cells in...
Feb 11, 2022
Geneticists Reveal How Mutation Causes a Devastating Childhood Cancer
Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable ...
Jul 26, 2021
Blocking copper uptake in tumor cells may be clue to boosting immune system
Researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to...
Aug 25, 2020
Brain Cancer in Infants Could Be Treated With Targeted Drugs
Brain cancer in infants is biologically distinct from other childhood brain tumors and could be successfully treated with targeted drugs,...
Apr 3, 2020
Two-Drug Combo Shows Promise in Treating Childhood Brain Cancers
Researchers have tested a new drug combination that shows promise for the treatment of several types of childhood brain cancers known as...
Nov 25, 2019