Dabrafenib and trametinib – a new treatment on the horizon?
Recent research suggests that there could be a new treatment on the horizon for some children diagnosed with low and high-grade gliomas....
Dec 18, 2023
Tafinlar Plus Mekinist Shows Benefits In Pediatric Glioma
A recent phase 2 trial revealed that the combination of Tafinlar and Mekinist benefitted children with BRAF-mutated low-grade gliomas....
Dec 12, 2023
Promising investigational therapy improves survival in aggressive childhood brain tumor
An international team of investigators has identified a drug candidate that nearly doubles survival rates for patients with diffuse ...
Dec 4, 2023
FDA Gives Priority Review to Tovorafenib in Pediatric Low-Grade Glioma
The FDA has granted priority review to a new drug application (NDA) for single-agent tovorafenib (DAY101) as a treatment for those with...
Nov 6, 2023
Lenalidomide Demonstrates Promising Activity in Pediatric Gliomas/Astrocytomas
The immunomodulatory agent lenalidomide (Revlimid) appeared clinically active and tolerable in pilocytic astrocytomas and optic pathway...
Jul 6, 2023
Developing novel treatments for childhood solid cancers
With a particular focus on glioma, Dr Peter J Houghton from Greehey Children’s Cancer Research Institute outlines the barriers that have...
Jul 4, 2023
New Drug Shows ‘Encouraging’ Outcomes for Pediatric Brain Tumor Treatment
Treatment with tovorafenib led to a 64% overall response rate in patients with recurrent or progressive pediatric low-grade glioma, study...
Jan 12, 2023
Dabrafenib + Trametinib Improve Overall Response Rates in Pediatric Patients with Low-Grade Gliomas
The combination of two targeted therapies, the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib, significantly increased the...
Jun 9, 2022
Study finds jumping 'junk' DNA is a novel cause of childhood brain cancer
Scientists have found a novel cause of aggressive pediatric brain cancer. The St. Jude Children's Research Hospital study is the first to...
Apr 26, 2022
Alcohol abuse drug may hold key to treating aggressive childhood brain tumours
Researchers at University College London have discovered that disulfiram, an anti-alcoholism drug, may help to kill glioma cells in...
Feb 11, 2022