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Research opens a window into understanding deadly brain tumors

Formerly known as diffuse intrinsic pontine gliomas, diffuse midline gliomas (DMGs) are highly aggressive tumors found in the midline of the brain. Their prognosis is very poor, in part because they don’t respond well to treatments such as chemotherapy and radiation. Now, research by Mariella Filbin, MD, PhD, and others in the Brain Tumor Center at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center has uncovered new details about how these rare tumors develop and grow that could someday inform specialized treatment options.



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