Extra Chromosomes and Chromosomal Instability Trigger Common Childhood Cancer

B-cell acute lymphoblastic leukaemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with an excess of chromosomes (hyperdiploidy), a condition that leads to chromosomal instability. Now, a study published in Cell Reports reveals that this chromosomal instability caused by hyperdiploidy reduces the proliferation of the affected cells, delays their differentiation and allows some to persist as rare, long-lived clones in the bone marrow, but without triggering leukaemia.

Read more: https://www.technologynetworks.com/tn/news/excess-chromosomes-and-chromosomal-instability-trigger-common-childhood-cancer-411623