Removing etoposide from frontline induction chemotherapy did not appear to negatively affect key outcomes for patients with pediatric acute myeloid leukemia (AML), according to recent findings from a Children’s Oncology Group (COG) clinical trial presented at the ASH Annual Meeting 2025. Read more: https://www.cancertherapyadvisor.com/reports/etoposide-safely-eliminated-pediatric-acute-myeloid-leukemia/

A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with the same leukemia-causing gene mutation can have dramatically different outcomes: it depends on when in development the mutation first occurs.   Read more: https://www.mountsinai.org/about/newsroom/2025/mount-sinai-study-finds-childhood-leukemia-aggressiveness-depends-on-timing-of-genetic-mutation

Nearly a third of families with children receiving chemotherapy for acute lymphoblastic leukemia (ALL) – the most common pediatric cancer – develop serious financial difficulties during their child’s treatment, including losing 25% or more of their household income and struggling to cover the costs of basic living expenses such as housing, food, and utilities. Read more: https://www.eurekalert.org/news-releases/1108761

A new type of cancer cell that “warrants urgent investigation” has been discovered in childhood leukaemia and could impact clinical care. Research into new or repurposed treatments that target this new cell type could give hope to children and families worldwide. Read more: https://www.eurekalert.org/news-releases/1105676

A new study led by researchers at the University of Minnesota Medical School has identified genetic factors that may help explain why African American children are less likely to develop acute lymphoblastic leukemia (ALL) but tend to face worse outcomes when they do. Read more: https://twin-cities.umn.edu/news-events/university-minnesota-study-uncovers-new-genetic-factors-childhood-leukemia

The new paper reveals for the first time that these DNA fragments can persist in cancer cells and may drive relapse in patients with...

Chemotherapy resistance is particularly common in what is known as T-ALL, a subtype of ALL. This recent study shows that the origin of...

As we age, some populations of immune cells change in abundance and these changes can be measured and used to infer one’s immunological...

Planned caesarean births—"C-sections"—slightly raise the risk of some childhood cancers—particularly acute lymphoblastic leukemia (ALL),...

Scientists at St. Jude  Children’s Research Hospital and University Health Network showed that the stage of B-cell development at which...