Dec 27, 2024
Menin inhibitor clinical trial puts pediatric leukemia patient in remission
“Patient response to revumenib has been good in other clinical trials,” explains Cuglievan. “But it’s also been short-lived when used...
Dec 24, 2024
Infantile Fibrosarcoma and Other Solid Tumors Respond Well to Precision Medicine
There’s new evidence that Larotrectinib (Vitrakvi), by Loxo Oncology and Bayer, is highly effective in children with newly diagnosed...
Dec 23, 2024
Why copper could be key to treating a rare childhood cancer
The survival rate for children with a rare but deadly cancer could one day be improved by adding an existing drug—which is currently used...
Dec 6, 2024
How a Penn State professor developed a cancer-fighting drug for kids
Giselle Saulnier Sholler has spent 20 years working treatments for neuroblastoma, a particularly aggressive form of early childhood...
Nov 28, 2024
Larotrectinib Is Promising for Pediatric TRK Fusion-Positive CNS Tumors
Larotrectinib led to rapid/durable responses and high disease control rates in children with TRK fusion-position central nervous system...
Nov 18, 2024
FDA Grants Rare Pediatric Designation to Elraglusib for Ewing Sarcoma
The FDA granted a rare pediatric disease designation to elraglusib (9-ING-41), a novel GSK-3β inhibitor, as a potential therapeutic...
Nov 8, 2024
Targeted therapy and radiation synergize in pediatric high-grade glioma
Research at St. Jude recently showed that the drug capmatinib is effective at crossing the blood-brain-barrier, synergizing with...
Nov 5, 2024
FDA Expands Approval for Jylamvo to Children With Acute Lymphoblastic Leukemia
The Food and Drug Administration (FDA) expanded the approval of Jylamvo (methotrexate) to include children with acute lymphoblastic...
Oct 15, 2024
New treatments offer hope for childhood cancer patients
Although the prognosis for most patients with pediatric cancer is good, one of the differences in treatment between childhood and adult...
Sep 27, 2024
Most cancer drugs must now be tested in paediatric cancers — unique PDX models can help
Approximately 75% of anticancer drugs must be tested against paediatric cancer. Drug developers can now use a database of patient-derived...